What is R-Alpha Lipoic Acid? 

R-alpha-lipoic acid (R-ALA), also known as (R)-lipoic acid, is a naturally occurring compound that serves as a cofactor for mitochondrial enzymes involved in energy metabolism. It is an organosulfur compound derived from octanoic acid and is synthesized in small amounts in the human body. R-ALA is considered the biologically active form of alpha-lipoic acid.

R-ALA exhibits powerful antioxidant properties due to its ability to scavenge free radicals and regenerate other antioxidants like vitamin C, vitamin E, and glutathione, enhancing the body’s overall antioxidant defense system. Additionally, R-ALA has been found to exert anti-inflammatory effects and may have neuroprotective properties, making it potentially beneficial for various health conditions.

Benefits of R-Alpha Lipoic Acid

1. Antioxidant Support: R-ALA helps neutralize free radicals, reducing oxidative stress and protecting cells from damage caused by reactive oxygen species.
2. Glucose Metabolism: R-ALA has been shown to improve insulin sensitivity and glucose uptake, potentially benefiting individuals with insulin resistance or type 2 diabetes.
3. Neuroprotection: R-ALA may have neuroprotective effects, including the ability to enhance cognitive function and protect against neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.
4. Cardiovascular Health: Studies suggest that R-ALA may help improve endothelial function, reduce inflammation, and lower blood pressure, thereby promoting cardiovascular health.
5. Liver Health: R-ALA has been investigated for its potential to protect the liver from damage caused by toxins, alcohol, and certain medications.

References:

1. Packer, L., Witt, E. H., & Tritschler, H. J. (1995). Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine, 19(2), 227-250. doi:10.1016/0891-5849(95)00017-r
2. Shay, K. P., Moreau, R. F., Smith, E. J., Smith, A. R., & Hagen, T. M. (2009). Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta (BBA) – General Subjects, 1790(10), 1149-1160. doi:10.1016/j.bbagen.2009.07.026
3. Gorąca, A., Huk-Kolega, H., Piechota, A., Kleniewska, P., Ciejka, E., Skibska, B., & Kryś, S. (2011). Lipoic acid – biological activity and therapeutic potential. Pharmacological Reports, 63(4), 849-858. doi:10.1016/s1734-1140(11)70600-3